Principal Scientist – Director, Oligonucleotide Therapeutics Discovery & Development

Principal Scientist – Director, Oligonucleotide Therapeutics Discovery &
Development
Location: BioBAY, Suzhou
Level: Middle-Senior Level
Full-Time

Responsibilities:
Oligonucleotide Design &
Optimization: Design, synthesize, and screen siRNA/ASO sequences to optimize target binding affinity, potency, stability, and specificity.
In Vitro Characterization: Develop and validate cell-based assays to assess siRNA/ASO activity: siRNA knockdown efficiency, ASO-mediated mRNA degradation/splicing modulation, off-target effects, cytotoxicity, and cellular uptake.
Delivery System Development: Collaborate with internal or external teams to design, optimize, and characterize delivery platforms for siRNA/ASO, including antibody conjugates, lipid nanoparticles (LNPs), and other targeted delivery systems in vitro/in vivo delivery efficacy.
Preclinical In Vivo Studies: Plan and execute preclinical studies in rodent/non-rodent models to assess siRNA/ASO Tissue-specific targeting and biodistribution, Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety.
Technology Innovation &
Trend Monitoring: Stay updated on the latest advancements in oligonucleotide therapeutics (siRNA/ASO design, chemical modifications, delivery technologies) and propose innovative strategies to address program challenges (e.g., reduced off-target effects).