Principal Scientist, Antibody Engineering

Structural Analysis & Project Evaluation: Possess in-depth knowledge of antibody structure and function, with particular experience in heavy-chain-only antibodies/nanobodies. Responsible for antibody sequence analysis and structural interpretation. Lead target-based structural background investigations, molecular mechanism studies, and early-stage technical feasibility assessments for antibody engineering projects. Antibody Engineering and Optimization: Lead antibody engineering and structure-based rational design to achieve affinity maturation, improved physicochemical properties, enhanced developability/druggability, and introduction of specialized features such as pH-dependent binding. Proficient in leveraging cutting-edge AI tools to optimize engineering workflows, significantly enhancing design efficiency, throughput, and accuracy. Technology Platform Development and Advancement: Spearhead the establishment, expansion, and continuous iteration of core technology platforms for antibody engineering and computational structure-based design. Monitor and adopt industry-leading computational and AI-assisted macromolecule design/optimization technologies to empower the team and boost overall R&D capabilities and productivity.