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负责治疗性抗体发现中的体外功能实验设计与优化,包括ELISA、FACS及细胞增殖实验;执行抗体筛选与表征流程,从初筛到先导化合物选择;分析数据并维护实验记录,推动新平台开发。
Design, perform, and optimize functional in vitro assays, including ELISA, flow-based reporter/blocking assays (FACS), and proliferation assays to evaluate antibody activity.
Establish and maintain primary cell cultures, and conduct primary cell-based functional assays to assess antibody mechanism of action.
Execute antibody screening and characterization workflows, from initial hit validation to lead selection, using both plate-based and cell-based readouts.
Analyze, interpret, and present experimental data with scientific rigor, drawing meaningful conclusions to guide project decision-making.
Maintain accurate and detailed experimental records, following company quality and documentation standards.
Contribute to the development of new assay platforms and process improvements to increase throughput and robustness.
Proven hands-on experience with ELISA, flow cytometry-based reporter/blocking assays, proliferation assays, and other functional readouts.
Solid experience with primary cell culture (e.g., immune cells, tumor cells) and functional assay design.
Antibody screening experience, including hit triaging and functional ranking of candidates.
Proficiency in data analysis using statistical software (e.g., GraphPad Prism, FlowJo, Excel).
Ability to work independently and manage multiple projects in a fast-paced environment.
(Preferred) Experience in therapeutic antibody drug discovery, including mechanism-of-action studies.
(Preferred) Knowledge of cell signaling pathways relevant to immuno-oncology, inflammation, or other therapeutic areas.
Proficient in applying AI tools in daily works.
研究和试验发展