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负责肿瘤生物药研发体外药理团队管理,主导抗体、蛋白及DNA疫苗的功能与生物分析检测开发;与抗体工程、体内药理、分析及PK等多部门协作推进项目;要求免疫学/药理学/细胞生物学博士,5年以上海外经验,有团队与项目领导经历。
岗位职责:
1. Manage scientific staff and external resources (academic and CROs) to deliver quality data in an efficient manner to support biological drug discovery programs for oncology.
2. Lead the development and execution of relevant functional and bioanalytical assays to support antibody, protein therapeutics and DNA vaccine development in the context of multidisciplinary project teams.
3. Provide quantitative assays for characterizing PK and biomarker PD to support in vivo studies.
4. Coordinate with antibody engineering, in vivo Pharmacology, Analytical, PK and safety groups to advance lead molecules of the projects.
5. Ensure compliance with departmental SOPs, safety guidelines, and other applicable regulations.
6. Manage and supervise study planning, protocol design, study implementation and result publishing.
7. Present project update and science to senior management.
任职要求:
1. Ph.D. in immunology, pharmacology, cell biology or a related field with minimum 5 years oversea working experience with significant group and project leadership responsibilities in academic or pharmaceutical industry.
2. Practical experience in the design, development, validation and execution of in vitro functional assays as well as bioanalytical assays for protein therapeutics is required.
3. Strong understanding of key components and process of drug discovery, pharmacology and drug development
4. Broad knowledge and working experience including but not limited to cellular and immunological assays, e.g. human/mouse primary cell isolation and culture, FACS, MLR, B/T cell activation/proliferation, macrophage differentiation, ADCC, ADCP, CDC etc. and molecular and biochemical assays e.g. Western, ELISA, FRET/AlphaLISA, Octet etc. to characterize antibodies or other biologics.
5. Strong communication skills and ability to work effectively across multiple multidisciplinary teams and across sites.
6. Proven track record to manage an in vitro pharmacology group in a matrixed environment.
【职位类别】研发类
【学历要求】博士研究生及以上
【招聘人数】1
【招聘项目】2025年关键岗位招聘
【所属公司】研发系统
1. Ph.D. in immunology, pharmacology, cell biology or a related field with minimum 5 years oversea working experience with significant group and project leadership responsibilities in academic or pharmaceutical industry.
2. Practical experience in the design, development, validation and execution of in vitro functional assays as well as bioanalytical assays for protein therapeutics is required.
3. Strong understanding of key components and process of drug discovery, pharmacology and drug development
4. Broad knowledge and working experience including but not limited to cellular and immunological assays, e.g. human/mouse primary cell isolation and culture, FACS, MLR, B/T cell activation/proliferation, macrophage differentiation, ADCC, ADCP, CDC etc. and molecular and biochemical assays e.g. Western, ELISA, FRET/AlphaLISA, Octet etc. to characterize antibodies or other biologics.
5. Strong communication skills and ability to work effectively across multiple multidisciplinary teams and across sites.
6. Proven track record to manage an in vitro pharmacology group in a matrixed environment.
水利管理业