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负责建立和优化siRNA药化平台，领导核酸药物研发团队，主导序列设计、化学修饰及递送技术开发，推动项目从早期发现到临床前候选化合物提名。要求博士学历及3年以上工业界经验，具备肝外递送系统设计经验者优先。
Key Responsibilities】
1. Platform Development
o Lead the establishment and optimization of siRNA medicinal chemistry platform, overseeing internal and external nucleic acid chemistry resources to drive technological innovation.
o Manage, mentor, and develop a high-performing nucleic acid drug discovery team, including strategic planning and talent development.
2. R&D Strategy & Execution
o Direct siRNA sequence design, chemical modification strategies, and conjugate technology development to enhance candidate potency, durability, and targeted delivery efficiency.
o Lead the chemical design and development of extra-hepatic delivery systems, exploring novel targeting ligands, lipids, and polymers to overcome targeting challenges beyond the liver.
o Integrate biological data and bioinformatics analysis for molecular optimization, advancing projects from early discovery to the nomination of Preclinical Candidates (PCC).
3. Cross-functional Collaboration & Project Management
o Collaborate closely with cross-functional teams (Biology, Pharmacology, DMPK, Toxicology, CMC) to coordinate resources and ensure efficient project progression.
o Manage external CRO partnerships, overseeing project timelines, budgets, and quality.
4. Intellectual Property & Regulatory Support
o Lead the drafting and filing of patents related to nucleic acid therapeutics to build a robust intellectual property portfolio.
o Support the preparation of IND enabling documents, ensuring the medicinal chemistry sections meet regulatory requirements.
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【Qualifications】
1. Education
o Ph.D. in Organic Chemistry, Medicinal Chemistry, Nucleic Acid Chemistry, or a related field.
2. Experience
o 3+ years of industry experience in oligonucleotide drug discovery, with a strong preference for candidates who have successfully advanced siRNA projects from early discovery into the clinical stage.
o Experience in designing extra-hepatic delivery systems (e.g., novel targeting ligands, LNPs, exosomes) is highly preferred.
3. Technical Skills
o Deep expertise in nucleic acid chemical synthesis, modification strategies (e.g., GalNAc conjugation, nucleotide modifications), and delivery technologies.
o In-depth understanding of novel delivery system design principles and hands-on experience with extra-hepatic targeting strategies.
o Solid understanding of siRNA mechanisms of action, stability optimization, and strategies to mitigate off-target effects.
o Keen insight into cutting-edge technologies and industry trends in the oligonucleotide therapeutics field.
4. Core Competencies
o Excellent English communication skills, capable of effectively interacting with international teams and external partners.
o Strategic thinker with strong innovation capabilities, able to drive technological breakthroughs in a rapidly evolving field.
o Results-oriented with strong project management skills and a collaborative spirit.
研究和试验发展
