生物执行总监

Main responsibilities

1.Project Initiation and Research

1）Lead and deeply participate

in biological research in the field of diseases, identify unmet clinical needs,

and evaluate emerging technology platforms.

2)

Be responsible for the project initiation research, scientific argumentation

and competitive landscape analysis of new drug projects, write project

initiation reports, and provide key decision-making basis for the company's

R&D strategy and pipeline layout.

3）Continuously track the

latest scientific research progress, patent trends and market competition

intelligence in related fields domestic and overseas.

2.New Target/Technology Discovery and

PCC Research

1)Lead

the discovery, evaluation and biological validation of new

targets/technologies, and design and implement key proof-of-concept studies.

2)Lead

an interdisciplinary team (including chemistry, pharmacology, etc.) to optimize

and screen lead molecules until preclinical candidate compounds (PCCS) are

established.

3)Deeply

clarify the mechanism of action (MOA), pharmacodynamic (PD) characteristics and

preliminary safety signals of the candidate molecules.

3.Preclinical development

1） Manage all research

work from the PCC stage to the application for clinical research (IND).

2）Participate in the

formulation and implementation of a comprehensive preclinical development plan,

including but not limited to: in vitro efficacy and mechanism studies, in vivo

disease model efficacy evaluation, drug metabolism and pharmacokinetic (DMPK)

studies, as well as safety pharmacology and toxicology studies that support IND

applications.

4.Team and Strategic Leadership

Form,

cultivate and manage an efficient team of early-stage R&D scientists.

As

the core leader of the project, I closely collaborated with departments such as

pharmacy and chemistry, pharmacology and toxicology, clinical studies, and

registration to ensure that the project goals were achieved on time and with

high quality.

Participate

in the formulation of the company's overall R&D strategy.

Job Requirements

1.Educational background

Possess

a doctoral degree in biological sciences, pharmacology, medicine or a related

field.

2.Work Experience

1）At least 8 years of

early-stage drug development experience in pharmaceutical or biotech companies,

with full-process successful experience from target discovery to preclinical

candidate compound (PCC) establishment and IND-enabling research.

2）Those with complete project

experience in globally renowned multinational pharmaceutical companies (MNC) or

leading domestic innovative pharmaceutical enterprises are preferred.

3）Have experience in team

management and cross-departmental project management.

3.Knowledge and Skills

1）Proficient in disease

biology, molecular and cellular biology, and pharmacological principles, with a

profound understanding of at least one core disease area such as tumors,

autoimmune diseases, metabolism, or the central nervous system.

2）Proficient in various in

vitro and in vivo experimental techniques and models, with outstanding

abilities in experimental design, data analysis and problem-solving.

3）Be familiar with the

regulations and guiding principles of drug research and development, and

understand the basic process and requirements of IND application.

4）Possess excellent

scientific judgment, strategic thinking and forward-looking vision.

5）Outstanding communication,

expression and leadership coordination skills in both Chinese and English.