核酸化学高级经理

Key Responsibilities】1. Platform Development &
Leadershipo Lead the establishment and optimization of siRNA medicinal chemistry platform, overseeing internal and external nucleic acid chemistry resources to drive technological innovation.o Manage, mentor, and develop a high-performing nucleic acid drug discovery team, including strategic planning and talent development.2. R&
D Strategy &
Executiono Direct siRNA sequence design, chemical modification strategies, and conjugate technology development to enhance candidate potency, durability, and targeted delivery efficiency.o Lead the chemical design and development of extra-hepatic delivery systems, exploring novel targeting ligands, lipids, and polymers to overcome targeting challenges beyond the liver.o Integrate biological data and bioinformatics analysis for molecular optimization, advancing projects from early discovery to the nomination of Preclinical Candidates (PCC).3. Cross-functional Collaboration &
Project Managemento Collaborate closely with cross-functional teams (Biology, Pharmacology, DMPK, Toxicology, CMC) to coordinate resources and ensure efficient project progression.o Manage external CRO partnerships, overseeing project timelines, budgets, and quality.4. Intellectual Property &
Regulatory Supporto Lead the drafting and filing of patents related to nucleic acid therapeutics to build a robust intellectual property portfolio.o Support the preparation of IND enabling documents, ensuring the medicinal chemistry sections meet regulatory requirements.________________________________________

【Qualifications】1. Educationo Ph.D. in Organic Chemistry, Medicinal Chemistry, Nucleic Acid Chemistry, or a related field.2. Experienceo 5+ years of industry experience in oligonucleotide drug discovery, with a strong preference for candidates who have successfully advanced siRNA projects from early discovery into the clinical stage.o Experience in designing extra-hepatic delivery systems (e.g., novel targeting ligands, LNPs, exosomes) is highly preferred.3. Technical Skillso Deep expertise in nucleic acid chemical synthesis, modification strategies (e.g., GalNAc conjugation, nucleotide modifications), and delivery technologies.o In-depth understanding of novel delivery system design principles and hands-on experience with extra-hepatic targeting strategies.o Solid understanding of siRNA mechanisms of action, stability optimization, and strategies to mitigate off-target effects.o Keen insight into cutting-edge technologies and industry trends in the oligonucleotide therapeutics field.4. Core Competencieso Excellent English communication skills, capable of effectively interacting with international teams and external partners.o Strategic thinker with strong innovation capabilities, able to drive technological breakthroughs in a rapidly evolving field.o Results-oriented with strong project management skills and a collaborative spirit.